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Tumor Immunology and Cancer Vaccines J. Koerting more precisely by deriving aIt all started with an observation. Edward Jenner, an English physician, observed that milkmaids who contracted cowpox were rarely victims of smallpox epidemic, a disease that in? icted a heavy toll on humankind with an estimate of 500 million victimsworldwide. In1796,Jennerinoculatedtheextracted? uidfromblistersonthe handofamilkmaidwhowasinfectedwithcowpoxintothearman8yearoldpeasant boy. After the boy recovered from a mild illness caused by this